Structural Classification of Toxic Amyloid Oligomers
نویسندگان
چکیده
منابع مشابه
Toxic fibrillar oligomers of amyloid-β have cross-β structure.
Although amyloid fibers are found in neurodegenerative diseases, evidence points to soluble oligomers of amyloid-forming proteins as the cytotoxic species. Here, we establish that our preparation of toxic amyloid-β(1-42) (Abeta42) fibrillar oligomers (TABFOs) shares with mature amyloid fibrils the cross-β structure, in which adjacent β-sheets adhere by interpenetration of protein side chains. W...
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Department of Chemistry, Ulsan Nationa (UNIST), Ulsan 44919, Republic of Korea. E Department of Chemistry, Pohang Universit Pohang 37673, Republic of Korea Department of Chemistry, Research Institu Seoul 02841, Republic of Korea. E-mail: hug Graduate School of Medical Life Science, Kanagawa 230-0045, Japan † Electronic supplementary information Fig. S1–S18 and Tables S1 and S2. See DO ‡ These a...
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Toxic amyloid beta oligomers (AβOs) are known to accumulate in Alzheimer's disease (AD) and in animal models of AD. Their structure is heterogeneous, and they are found in both intracellular and extracellular milieu. When given to CNS cultures or injected ICV into non-human primates and other non-transgenic animals, AβOs have been found to cause impaired synaptic plasticity, loss of memory func...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.r800016200